See also: Kosher wine, Christianity and alcohol, and Islam and alcohol

The use of wine in religious ceremonies is common to many cultures and regions. Libations often included wine, and the religious mysteries of Dionysus involved wine as a sacramental entheogen.

Wine plays an integral part of Jewish laws and traditions. The Kiddush, a blessing said before starting the first and second Shabbat or festival meals and Havdallah, a blessing said after the Shabbat or festival are required to be said over wine if available. On Pesach (Passover) during the Seder, it is also required to drink four cups of wine.[51] In the Tabernacle and in the Temple in Jerusalem, the libation of wine was part of the sacrificial service.[52] Note that this does not mean that wine is a symbol of blood, a common misconception which contributes to the myth of the blood libel. A blessing over wine said before indulging in the drink is: "Baruch atah Hashem elokeinu melech ha-olam, boray p’ree hagafen" (Praised be the Eternal, Ruler of the universe, who makes the fruit of the vine).

In Christianity, wine or grape juice is used in a sacred rite called the Eucharist, Lord's Supper, or Communion, which originates in Gospel accounts of the Last Supper when Jesus shared bread and wine with his disciples and commanded his followers to "do this in remembrance of me" (Gospel of Luke 22:19). Beliefs about the nature of the Eucharist vary between denominations, with Roman Catholics believing that the bread and wine are changed into the real body and blood of Christ.

Wine was used in the rite by all Protestant groups until an alternative arose in 1869. Methodist minister-turned-dentist Thomas Bramwell Welch applied new pasteurization techniques to stop the natural fermentation process of grape juice. The substitution of grape juice for wine spread quickly over much of the United States in Protestant rites, although the beverage is usually called wine in accordance with scriptural references.[53] Some Christians who were part of the growing temperance movement pressed for a switch from wine to grape juice. There remains an ongoing debate between some American Protestant denominations as to whether wine can or should be used in moderation for the Eucharist or as a regular beverage.

The use of wine is forbidden under Islam. Iran used to have a thriving wine industry that disappeared after the Islamic revolution in 1979.[54]

Health Effects of Wine